All ISCAR preparations are indicated as homeopathic medications for adjunct treatment of cancerous conditions, apathy, sadness, constipation and internal thermo-regulation problems. We also found a prospective, randomised, controlled trial in which colorectal cancer patients seemed to benefit in terms of survival from combined postoperative chemotherapy and i. Preliminary results of a qualitative study on physicians applying i. We therefore believe that the relative frequency of 4. Whether the lower frequency of ADRs in i. Studies comparing the half-life of mistletoe lectins and other molecules of comparable size after application by s.
As described previously, documentation officers extract patient information, cancer diagnoses, therapies, adverse events, and disease progress from patient files and record data using the QuaDoSta Quality management, Documentation, and Statistics software that was developed at Havelhoehe Research Institute [ 26 , 29 ]. All analyses were conducted and figures were created with R version 2. Subscribe to free Drugs. On the other hand, this study attempted to provide an accurate picture of the clinical use of i. After one year of treatment, if progress is satisfactory, the physician may recommend a 1-week injection-free interval following every sequence of 14 injections. The present study summarised the use of i. Overall, exposure to high doses of mistletoe did not appear to increase the frequency of ADRs.
Always consult your healthcare provider to ensure the information displayed on this page isdador to your personal circumstances. The present study describes the use of i. Considering that tumours of the lung, breast, colorectal, and pancreas were the most frequent cancer entities, a high frequency of exposure to Mali and Abietis preparations was expected. Irradiated areas and inflamed skin areas should be avoided. Basic information about patients treated with i. Iscador Mali special, Abnoba viscum Quercus, Iscador Mali, and Iscador Quercus show the highest relative frequencies of all preparation types.
They are homeopathic, sterile injectables for subcutaneous use.
Analysis of Safety Data All mistletoe-related adverse events reported by physicians were assessed by the investigators. Therefore, only for Iscador was seried median ADR dose Detailed information about mistletoe therapies seried, including dosage data, therapy start and end dates, and related adverse events, is documented. Other possible explanations for the difference in ADR frequencies relate to differences in the way i.
Improvements in well-being and quality of life are the most commonly reported, particularly in frail patients with mapi or end-stage cancer, or beneficial effects regarding cancer-related low mood, fatigue, and pain [ 3612 — 16 ]. This may be done by reducing the frequency of injection or by using a fraction of an ampule. The numbers of patients exposed to different preparation types vary largely, however, making it difficult to draw strong conclusions regarding associations of increased ADR risk with certain preparation types.
Treatment with intravenous mistletoe applications is described.
Study Design and Data Sources A multicentre, observational study was carried out iscaeor the Network Oncology NOa conjoint clinical registry of German hospitals and out-patient practitioners specialised in anthroposophic medicine [ 2628 ]. ADR frequency differed with respect to preparation type, with Iscador preparations showing a higher relative frequency, compared to Abnoba viscum and Helixor.
Therefore, there is an increased opportunity for patients receiving s. The best time tends to be in the mornings, or when the body temperature naturally rises. According to product information, mistletoe preparations with high concentrations of lectins and viscotoxins e. UpToDate, http: As a result, prospective studies assessing the efficacy of i. Decisions of causality were made based on consideration of the dates of mistletoe infusion, of the adverse event, and of other therapies received and on therapy types and doses received, and whether reactions made sense based on known pharmacological activity of therapies and on patient history.
Female gender has previously been identified as a risk factor for experiencing an ADR, while late stage cancer is associated with a suppressed immune system and might have contributed to a lower frequency of ADRs in i. Increasingly mistletoe preparations are also applied at high initial doses, either by s. On the other hand, this study attempted to provide an accurate picture of the clinical use of i.
Of these, one patient experienced pyrexia Data were recorded in the QuaDoSta between and and analysed in In terms of ADRs, i. In clinical practice, i. In order to examine whether experiencing an ADR might be dose dependent, the doses at which patients experienced ADRs were considered in relation to the doses to which patients were exposed.
Out of 15 patients that continued i. Abnoba viscum doses ranged from 0. There was no control group for this study, meaning that ADRs may have been overreported due to our inability to calculate the frequency of disease-related, other therapy-related, or spontaneous adverse events. Overall, exposure to high doses of mistletoe did not appear to increase the frequency of ADRs. The other authors declare that they have no competing interests.
Traditional mistletoe therapy in cancer patients involves subcutaneous applications of Viscum album L. You accept the aforementioned information by continuing on to the external page.
Iscar Mali Injection Information from
In the cases where i. View at Google Scholar F. On the other hand, s. This material is provided for educational purposes only mxli is not intended for medical advice, diagnosis or treatment.
It is not surprising that most ADRs were systemic reactions rather than local reactions since i. Seties ordering, please be sure to specify the “host” type and strength desired.
Application frequencies, durations of therapy, and whether other non-i. All ISCAR preparations can be used during chemotherapy, hormone or radiation therapy; interactions with other drugs are unknown.
Evidence-Based Complementary and Alternative Medicine
It is possible that an effect of dose on the malj of patients having an ADR is not clear due to their being too few events for a concise investigation. We also found a prospective, randomised, controlled trial in which colorectal cancer patients seemed to benefit in terms of survival from combined postoperative chemotherapy and i.
In order to investigate whether administration of high doses is associated with an increased risk of experiencing an ADR, doses at which ADRs occurred must be assessed in iscadod to the doses to which patients were exposed Figure 2.
Orange, Mistletoe therapy for cancer patients [M. Looking for distributors in your area? The patients consisted of males Intravenous infusion of high doses may improve therapeutic outcomes and is becoming more common.